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Neomercazole
Neomercazole tablets are indicated in the management of hyperthyroidism, thyrotoxicosis (including thyroid storm), and also for the preparation of patients for thyroidectomy
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About:
Neomercazole is an anti-thyroid substance which depresses the formation of thyroid hormone. It reduces the uptake and concentration of inorganic iodine by the thyroid but its main effect is to reduce the formation of di-iodotyrosine and thyroxine.
It is absorbed rapidly from the gastro-intestinal tract and is widely distributed throughout the body. Neomercazole is completely metabolised to methimazole and it is the metabolite that is responsible for its clinical activity.
Neomercazole readily crosses the placental barrier and also attains a high concentration in the milk of lactating patients. Excretion in the urine is rapid. The elimination half-life of methimazole may be increased in hepatic and renal impairment.
How Taken:
Daily according to the severity of the disorder. The dose should be gradually reduced to the smallest amount which will control the disease. Daily dosage should be divided.
Missed Dose:
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once. If you miss more than 1 dose in a day, check with your doctor.
Overdose:
Overdosage or accidental poisoning may result in hypothyroidism and goitre. If blood dyscrasias occur, the drug should be immediately withdrawn. Further treatment is symptomatic and supportive.
Storage:
Store in a cool place below 25ТАC. Keep tightly closed. Store in the original container.
Side Efeects:
Side-effects may include rash, pruritis, skin pigmentation, paraesthesias, urticaria, headache, arthralgia, and gastro-intestinal disturbances (including nausea, vomiting and gastric discomfort), and abnormal hair loss.
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